The Effects of Iron-Mediated Oxidative Stress in Isolated Renal Cortical Brush Border Membrane Vesicles at Normothermic and Hypothermic Temperatures

R. Horton Department of Biochemistry Royal Free Hospital School of Medicine, University, of London, Rowland Hill St, London, NW3 2PF, UK; Surgery, Royal Free Hospital School of Medicine, University, of London, Rowland Hill St, London, NW3 2PF, UK

Catherine Rice-Evans Department of Biochemistry Royal Free Hospital School of Medicine, University, of London, Rowland Hill St, London, NW3 2PF, UK

B. J. Fuller Surgery, Royal Free Hospital School of Medicine, University, of London, Rowland Hill St, London, NW3 2PF, UK

Abstract

Experiments on renal cortical brush border membrane vesicles have been undertaken in order to assess the involvement of iron in oxidative stress at physiological temperatures and under conditions of hypothermia. A decrease in temperature stimulated iron-induced lipid peroxidation. The results are discussed in relation to the role of the oxidation state of the iron and iron(II)/iron(III) ratios in the initiation of peroxidative events.

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The Effects of Iron-Mediated Oxidative Stress in Isolated Renal Cortical Brush Border Membrane Vesicles at Normothermic and Hypothermic Temperatures

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The Effects of Iron-Mediated Oxidative Stress in Isolated Renal Cortical Brush Border Membrane Vesicles at Normothermic and Hypothermic Temperatures

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