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Abstract
RRR-alpha-Tocopherol (Vitamin E) was assayed in plasma of 48 patients with viral hepatitis and of 32 healthy controls. In patients with highly elevated serum transaminases (ALT <100 U/L) vitamin E plasma levels were significantly lower (17.5 ± 4.8 μmol/L) than in controls (22.7 ± 4.2 μmol/L, p < 0.01). The vitamin E/ lipid ratios (3.12 ± 0.63 μmol/g) in these patients were 33% lower than those of the controls (4.68 ± 0.54 μmol/g). The lowered vitamin E levels in patients with acute or chronic viral hepatitis with high activity of disease may be due to free radical-mediated liver injury.