Unidentified Antioxidant Defences of Human Plasma in Immobilized Patients: A Possible Relation to Basic Metabolic Rate

R. Aejmelaeus Laboratory of Neurobiology, Medical School, University of Tampere, PO Box 607, 33101, Tampere, Finland

T. Metsä-Ketelä Department of Pharmacological Sciences, Medical School, University of Tampere, PO Box 607, 33101, Tampere, Finland

T. Pirttilä Department of Neurology, Tampere University Hospital, P.O. Box 2000, 33521, Tampere, Finland

A. Hervonen Department of Gerontology, School of Public Health, University of Tampere. PO Box 607, 33202, Tampere, Finland

H. Alho Laboratory of Neurobiology, Medical School, University of Tampere, PO Box 607, 33101, Tampere, Finland; Department of Alcohol Research, National Public Health Institute, POB 719, 00101, Helsinki, Finland, Ted +358–0–133 3339, Fax +358–0–133 2782

Abstract

Plasma total peroxyl radical scavenging capacity was studied in terminal patients who were chronically immobilized because of an acute (stroke) or chronic neurodegenerative disease (Alzheimer's disease). A luminometric assay was used to measure total antioxi-dant capacity (TRAP). The immobilized patients showed significant decrease in TRAP primarily because of a decrease in the concentration of unknown antioxidants. Our results suggest that human plasma may contain unknown antioxidants, the regulation of which could be related to the basic metabolic rate.

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Unidentified Antioxidant Defences of Human Plasma in Immobilized Patients: A Possible Relation to Basic Metabolic Rate

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Unidentified Antioxidant Defences of Human Plasma in Immobilized Patients: A Possible Relation to Basic Metabolic Rate

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