Progress toward an Orthotopic Cardiac Prosthesis

J. H. Kennedy Cora and Webb Mading Department of Surgery, Taub Laboratories for Mechanical Circulatory Support Baylor College of Medicine, Houston, Texas, 77025

M. E. Debakey Cora and Webb Mading Department of Surgery, Taub Laboratories for Mechanical Circulatory Support Baylor College of Medicine, Houston, Texas, 77025

W. W. Akers Cora and Webb Mading Department of Surgery, Taub Laboratories for Mechanical Circulatory Support Baylor College of Medicine, Houston, Texas, 77025

J. N. Ross Cora and Webb Mading Department of Surgery, Taub Laboratories for Mechanical Circulatory Support Baylor College of Medicine, Houston, Texas, 77025

W. O'bannon Cora and Webb Mading Department of Surgery, Taub Laboratories for Mechanical Circulatory Support Baylor College of Medicine, Houston, Texas, 77025

L. E. Baker Cora and Webb Mading Department of Surgery, Taub Laboratories for Mechanical Circulatory Support Baylor College of Medicine, Houston, Texas, 77025

S. D. Greenberg Cora and Webb Mading Department of Surgery, Taub Laboratories for Mechanical Circulatory Support Baylor College of Medicine, Houston, Texas, 77025

D. W. Wieting Cora and Webb Mading Department of Surgery, Taub Laboratories for Mechanical Circulatory Support Baylor College of Medicine, Houston, Texas, 77025

C. W. Lewis Cora and Webb Mading Department of Surgery, Taub Laboratories for Mechanical Circulatory Support Baylor College of Medicine, Houston, Texas, 77025

M. Adachi Cora and Webb Mading Department of Surgery, Taub Laboratories for Mechanical Circulatory Support Baylor College of Medicine, Houston, Texas, 77025

C. P. Alfrey Cora and Webb Mading Department of Surgery, Taub Laboratories for Mechanical Circulatory Support Baylor College of Medicine, Houston, Texas, 77025

W. J. Spargo Cora and Webb Mading Department of Surgery, Taub Laboratories for Mechanical Circulatory Support Baylor College of Medicine, Houston, Texas, 77025

J. M. Fuqua Rice University, Houston, Texas, 77001

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Abstract

This is a report emanating from a 31-member interdisciplinary group, some with 10 years experience in artificial heart research. The development of an implantable, biventicular orthotopic cardiac prosthesis is described, and the result of 24 calf experiments are summarized. Rather than pursuing solely long-term survival, the team has sought an understanding of the pathophysiological mechanisms which have limited the duration of such experiments to date.

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Progress toward an Orthotopic Cardiac Prosthesis

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Progress toward an Orthotopic Cardiac Prosthesis

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