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Original Article

Lack of Oncogenesis by Cross-Linked Polystyrene

, , , &
Pages 147-156 | Received 05 Mar 1974, Published online: 11 Jul 2009
 

Abstract

Three hundred and thirty mice of three strains (BALB/c, C57BL/6, CB6F) received either intrapetitoneal saline Injection of equal volumes of polystyrene microspheres at control state, 1% cross-linked, and 10% cross-linked at 8 Mrads/hr or 80 Mrads/hr gamma radiation, respectively. After 14 months, only one animal (C57BL/6, 1% cross-linked polymer) developed an intraperitoneal lymphosar-coma, while three control animals developed similar tumors, and two developed suspicious atypical lympho-proliferative lesions.

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