Nonthrombogenic ac Polarized Copper Prosthesis

Abstract

In previous studies from our laboratories, it was shown that metals and alloys which register negative potentials in blood vs the normal hydrogen electrode tend to be antithrombogenic while those with positive potentials are invariably thrombo-genic. The present paper deals with a novel approach of maintaining an implanted metallic prosthesis at a negative potential. A copper vascular prosthesis in a dog was maintained at cathodic potentials by a small amplitude (±100 mV) high-frequency ac (100 kHz) on the prosthesis. The prostheses were removed after 2 hours, 6 hours, 1 day, and 42 days, with subsequent visual and scanning electron microscopic examination of the prostheses completed. All tubes were free of thrombus deposits. Minimal junctional thrombi were found, probably due to differences in physicochemical characteristics of the vascular prostheses and recipient vessels. The results are compared with those in the control group (copper tubes with no current) and dc polarized copper tubes. While the control tubes occluded in 2 to 6 hours, the dc and ac polarized tubes remained patent. Of the ac and dc polarized tubes, the former tubes lasted up to 6 weeks with less thrombus deposit. The mechanism of operation of the ac polarized copper prosthesis is not fully understood.