Control of the Pilocarpine Release Rate Through Hydrogels by Plasma Treatment

Abstract

The rate of release of an aqueous solution of pilocarpine hydrochloride sequestered in hydrogel-type materials can be reduced by plasma treatment of the polymer surface. Two plasma techniques were used. The first involves exposure of the hydrogel to the effects of a glow discharge sustained in argon, a process known as CASING. (Crosslinking by Active Species of Inert Gases). The second technique involves the deposition of a thin film by plasma polymerization of organic gases. The gases used in this study were ethane, ethylene and tetrafluoroethylene. Hydrogels were prepared by photopolymerization of 2-hydroxymethyl methacrylate (HEMA), and copolymerization of HEMA with methyl acrylate. The CASING treatment was found to be least effective. The most successful method was the plasma polymerization of tetrafluoroethylene, which yielded an order of magnitude reduction in the flux rate of pilocarpine with a film thickness of 0.25μ;m. Polymerization conditions bringing about a crack-resistant film were critical in obtaining the best results.