Comparative Studies of Hemoperfusion Devices II. Pressure Drop and Flow Uniformity Tests

Abstract

One resin-based hemoperfusion device and three charcoal-based hemoperfusion devices were tested to determine their pressure drop and flow uniformity characteristics. Measurements were made on pressure drop versus flow rate using distilled water and on pressure drop versus time using bovine blood. Effluent concentration curves obtained after the step-change introduction of a high molecular weight dye solution to each unit were used to determine the priming volumes of the devices and were interpreted to yield information regarding the uniformities of flow in each device. The pressure drop and priming volume values for the resin-based device were significantly higher than the corresponding values for the charcoal-based units.