Lung Injury and Endogenous Intoxication: Interrelation and Sorption Detoxication Capacity

Abstract

The endogenous intoxication occuring in sepsis, trauma or marked dysfunction of the excretory system is often followed by Acute Pulmonary Injury. A sharp correlation was observed between the loss of the pulmonary function and structure and the blood concentration of active substances, i.e.; toxic peptides and other toxemia metabolites. The humoral and cellular lung injury mediators rate is elevated and the damage of the pulmonary endothelial membranes due to lipids peroxide oxidation reactions is observed. The method for severe lung injury treatment with the help of charcoal hemoperfusion and membrane oxygenation was developed both in experiment and clinic. The advantages of veno-arterial circuit of perfusion in pulmonary circulation, microcirculation stabilisation, reducing both the level of toxic substances entering the lungs and the pulmonary injury mediators capable of damage to the systemic circulation were established. In less harmful lung injury dentero sorption is likely to be used for the detoxication.