Allosteric Behavior of Artificial Compounds

Abstract

The artificial allosteric molecules were prepared by connecting two independent metal porphyrin molecules by convalent bond. These molecules as fragments behave very similary to the monomeric metal porphyrins except adsorption dissociation characteristics. In this paper we would like to discuss mostly on interesting and useful cooperativity or cooperative binding dissociation of small molecules like CO, O₂, or base to both of porphyrin metals. The original structure of the dimeric porphyrin, especially when they are very strongly cooperative, usually needs chemical strain between two porphyrin rings and this strain is released by the first binding of small molecule which causes coordinating change of the metal porphyrin.