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Abstract
More than 20 years ago, perfluorochemicals (PFC) were first used as biological oxygen transport substances in different ways:
a. by Clark and Gollan (1) in liquid breathing experiments using liquid PFC.
b. by Sloviter and Kamimoto (2) to perfuse an Isolated rat brain with an emulsion of PFC.
c. by Geyer, Monroe and Taylor (3) to replace nearly all the blood of rats with an emulsion of PFC.
These experiments showed unequivocally that PFC preparations effectively transport and deliver oxygen to living organs and animals. Since that time, many investigators have done very many experiments with PFC emulsions as blood substitutes, but PFC preparations have not been used clinically, except for very limited use In special circumstances (4). No PFC preparation has been approved for clinical use as a blood substitute, presumably because no available preparation has been shown to be adequate in safety and efficacy.