Oxygenation Effect of Fluosol-Da on Hypoxic Tumor Tissue and Retention of PFCs in the Tumor-Bearing Rats

Abstract

An i.v. injection of Fluosol-DA 20% without hydroxy-ethylstarch in combination with cartoqen (95% Oz and 5% COz) elevated dose-dependently the tumor POz in AH-109A tumor-bearing rats. The elevation of the tumor PO₂ by the treatment of Fluosol-DA injection and carbogen breathing was significantly high at the period when the elevated tumor blood flow declined to the original level and lasted for 3 hours following Fluosol injection. Saline injection with carbogen induced a small increase in the tumor PO₂. These results suggest that the oxygenation effect of Fluosol was primarily attributed to the oxygen carrying effect of Fluosol itself. The tumor PO₂ increased almost linearly with the arterial PO₂. The enhancement in tumor growth delay was observed on the 1 hour post 60CO -ray irradiation with carbogen following Fluosol injection in the Lewis lung tumor-bearing BDF; mice, but not with the 1 day-post irradiation. No significant differences were observed in perfluorochemical retention from the blood circulation and in organ distribution between the tumor bearing rats and normal rats.