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Abstract
Antipyrine disposition in conscious, unrestrained rats after 50% hemodilution with Fluosol or 0.9% sodium chloride (saline) has been reported (1). A similar study was conducted in animals 25% hemodiluted with Fluosol or saline to determine the effect of the percentage of hemodilution on antipyrine kinetics. Hemodiluted rats received an intravenous antipyrine dose (20 mg/kg) 0.5, 24, 48, or 72 hours after the exchange procedure, and were compared to non-exchanged (control) animals.