Effect of Enterosorption on Animal Lifespan

V. V. Frolkis Institute of Gerontology AMS USSR, Vyshgorodakaya St. 67, 252655, Xiev-114, USSR

V. G. Nikolaev Institute of Gerontology AMS USSR, Vyshgorodakaya St. 67, 252655, Xiev-114, USSR

G. I. Paramonova Institute of Gerontology AMS USSR, Vyshgorodakaya St. 67, 252655, Xiev-114, USSR

E. V. Shchorbitskaya Institute of Gerontology AMS USSR, Vyshgorodakaya St. 67, 252655, Xiev-114, USSR

L. N. Bogatskaya Institute of Gerontology AMS USSR, Vyshgorodakaya St. 67, 252655, Xiev-114, USSR

A. S. Stupina Institute of Gerontology AMS USSR, Vyshgorodakaya St. 67, 252655, Xiev-114, USSR

A. I. Kovtun Institute of Gerontology AMS USSR, Vyshgorodakaya St. 67, 252655, Xiev-114, USSR

V. E. Sabko Institute of Gerontology AMS USSR, Vyshgorodakaya St. 67, 252655, Xiev-114, USSR

V. M. Shaposhnikov Institute of Gerontology AMS USSR, Vyshgorodakaya St. 67, 252655, Xiev-114, USSR

Kh. K. Muradian Institute of Gerontology AMS USSR, Vyshgorodakaya St. 67, 252655, Xiev-114, USSR

N. P. Adamenko Institute of Gerontology AMS USSR, Vyshgorodakaya St. 67, 252655, Xiev-114, USSR

S. M. Novikova Institute of Gerontology AMS USSR, Vyshgorodakaya St. 67, 252655, Xiev-114, USSR

V. K. Koltovor Institute of Gerontology AMS USSR, Vyshgorodakaya St. 67, 252655, Xiev-114, USSR

S. N. Gorban Institute of Gerontology AMS USSR, Institute of Oncology, AS UkrSSR, Kiev

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Abstract

Experiments were performed on Wistar male rats, starting from the 28th month of age. The effect of dietary sorbent (non coated nitrogen-containing carbon administered as 10 day courses at 1 month intervals in dosage of 10 ml/kg) on lifespan and a number of biological indices were studied. Enterosorption resulted in the increase of mean and maximal lifespan by 43 and 34% respectively. Analysis of the effect of enterosorption on activity of microsomal enzymes, intensity of total RNA and protein biosynthesis, lipid metabolism, formation of free radicals etc. showed that it produced a positive influence on the functional state of the studied systems and increased the organism's adaptive capacities. Enterosorption was found to delay the rate of onset of age-related structural changes in the organs and tissues.

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Effect of Enterosorption on Animal Lifespan

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Effect of Enterosorption on Animal Lifespan

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