Comparison of the Cardioprotective Effect of Deoxygenated Hemoglobin-based Oxygen Carrier (HBOC) Pretreatment and Ischemia Preconditioning

Abstract

This study was designed to compare the influence of deoxygenated hemoglobin-based oxygen carrier (HBOC) pretreatment and ischemia preconditioning on cardiac ischemia/reperfusion (I/R) injury. Langendorff-perfused rat hearts were pretreated with 0.1 gHb/dL deoxygenated HBOC or ischemia, then subjected to 50-min warm ischemia and 2-hr reperfusion. The results indicated that deoxygenated HBOC pretreatment and ischemia preconditioning both equally improved the recovery of cardiac function, and reduced the cardiac enzyme release and myocardial histopathological changes as compared to the control group. Therefore our study demonstrated that deoxygenated HBOC pretreatment and ischemia precondition provided equivalent protection to the isolated heart against I/R injury.

Keywords::

• hemoglobin-based oxygen carrier
• pretreatment
• ischemia preconditioning
• ischemia/reperfusion injury

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.