Development of Resin Adsorbents for Blood Purification at Nankai University in China

Abstract

Various types of porous resin adsorbents based on polystyrene, agarose, and cellulose as matrixes coupling with DNA, amino acids and other biological active molecules as ligands were extensively studied in China. Molecular recognition between the ligand and pathogenic molecule was investigated. Several commercialized products are now widely used in hospitals all over China. Whole blood hemoperfusion is used to treat patients suffering from autoimmune diseases, uremia acute intoxication, and hyperbilirubinemia. Clinical performances of hundreds and thousands of patients treated by whole blood sorption therapy show that the therapy is safe, efficient, and cost-effective.

Keywords::

• resin adsorbent
• whole blood purification
• autoimmune disease
• detoxification
• hemoperfusion

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.