Pre-hospital Resuscitation with HBOC-201 and rFVIIa Compared to HBOC-201 Alone in Uncontrolled Hemorrhagic Shock in Swine

Ashraful HaqueNaval Medical Research Center, Operational and Undersea Medicine Directorate, NeuroTrauma Department, Silver Spring, MD, USACorrespondenceashraful.haque@ med.navy.mil

Françoise ArnaudNaval Medical Research Center, Operational and Undersea Medicine Directorate, NeuroTrauma Department, Silver Spring, MD, USA;Uniformed Services University of the Health Sciences, Department of Surgery, Bethesda, MD, USA

Kohsuke TeranishiNaval Medical Research Center, Operational and Undersea Medicine Directorate, NeuroTrauma Department, Silver Spring, MD, USA

Tomoaki OkadaNaval Medical Research Center, Operational and Undersea Medicine Directorate, NeuroTrauma Department, Silver Spring, MD, USA

Bobby KimNaval Medical Research Center, Operational and Undersea Medicine Directorate, NeuroTrauma Department, Silver Spring, MD, USA

Paula F. Moon-MassatNaval Medical Research Center, Operational and Undersea Medicine Directorate, NeuroTrauma Department, Silver Spring, MD, USA

Charles AukerNaval Medical Research Center, Operational and Undersea Medicine Directorate, NeuroTrauma Department, Silver Spring, MD, USA;Uniformed Services University of the Health Sciences, Department of Military and Emergency Medicine and Department of Neurology, Bethesda, MD, USA

Richard McCarronNaval Medical Research Center, Operational and Undersea Medicine Directorate, NeuroTrauma Department, Silver Spring, MD, USA

Daniel FreilichNaval Medical Research Center, Operational and Undersea Medicine Directorate, NeuroTrauma Department, Silver Spring, MD, USA

Anke H. ScultetusNaval Medical Research Center, Operational and Undersea Medicine Directorate, NeuroTrauma Department, Silver Spring, MD, USA;Uniformed Services University of the Health Sciences, Department of Surgery, Bethesda, MD, USA

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Abstract

Abstract: In a previous dose escalation study our group found that combining 90μg/kg rFVIIa with HBOC-201 reduced blood loss and improved physiologic parameters compared to HBOC alone. In this follow-up study in a swine liver injury model, we found that while there were no adverse hematology effects and trends observed in the previous study were confirmed, statistical significance could not be reached. Additional pre-clinical studies are indicated to identify optimal components of a multifunctional blood substitute for clinical use in trauma.

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Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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Pre-hospital Resuscitation with HBOC-201 and rFVIIa Compared to HBOC-201 Alone in Uncontrolled Hemorrhagic Shock in Swine

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Pre-hospital Resuscitation with HBOC-201 and rFVIIa Compared to HBOC-201 Alone in Uncontrolled Hemorrhagic Shock in Swine

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