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Research Article

Nanoparticles Based on Hydrophobic Alginate Derivative as Nutraceutical Delivery Vehicle: Vitamin D3 Loading

, , , , , & show all
Pages 113-119 | Published online: 02 Aug 2011
 

Abstract

Abstract: We report the application of Vitamin D3 (VD3) in nanoparticles of oleoyl alginate ester (OAE)(OAE-VD3). The internalization of fluorescent OAE-VD3 by Caco-2 cells was visualized by confocal laser scanning microscopy. In vivo pharmacokinetic studies showed that incorporation into OAE nanoparticles resulted in increased absorption of VD3. Its application in the treatment of rickets was assayed using a model of nutritionally induced vitamin D-deficiency rickets. The results showed that the encapsulated VD3 had better efficacy than that of the free drug in vivo. Our studies provide evidence that OAE nanoparticles are valuable as nutraceutical delivery vehicles to enhance the absorption of VD(3).

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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