Towards An Artificial Cornea: Surface Modifications of Optically Clear, Oxygen Permeable Soft Contact Lens Materials by Ammonia Plasma Modification Technique for the Enhanced Attachment and Growth of Corneal Epithelial Cells

R. Sipehia Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, 3655 Druramond Street, Montreal, Quebec, Canada, H3G 1Y6

A. Garfinkle Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, 3655 Druramond Street, Montreal, Quebec, Canada, H3G 1Y6

W. B. Jackson Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, 3655 Druramond Street, Montreal, Quebec, Canada, H3G 1Y6

T. M. S. Chang Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, 3655 Druramond Street, Montreal, Quebec, Canada, H3G 1Y6

Abstract

The advent of high water content, oxygen permeable contact lens materials has made the intracorneal implants more feasible. A major obstacle encountered is the regrowth of a stable epithelium over the implant. Therefore, ammonia gaseous plasma modification technique was used to modify the surface chemical properties of soft contact lens material such as poly(2-hydroxyethyl methacrylate and methacrylic acid), PHEMA-MAA copolymer, in an attempt to enhance the cell attachment and growth of rabbit corneal epithelial cells.

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Towards An Artificial Cornea: Surface Modifications of Optically Clear, Oxygen Permeable Soft Contact Lens Materials by Ammonia Plasma Modification Technique for the Enhanced Attachment and Growth of Corneal Epithelial Cells

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Towards An Artificial Cornea: Surface Modifications of Optically Clear, Oxygen Permeable Soft Contact Lens Materials by Ammonia Plasma Modification Technique for the Enhanced Attachment and Growth of Corneal Epithelial Cells

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