Telomeric Tham-Derived Perfluoroalkylated Surfactants for Fluorocarbon Emulsions

Summary

New fluorophilic and hydrophilic, cost efficient telomeric surfactants derived from tris(hydroxymethyl)acrylaminomethane were synthesized in 2 steps in 80% yield with respect to the perfluoroalkylated tclogcn. They demonstrate better ability to emulsify fluorocarbons than Pluronic F-68®. The biological tolerance of these new surfactants is remarquable, the perfluorohexyl derivative was tolerated at doses of 4g/kg bw after i.v. injection in mice. None of the perfluoroalkylated THAM derivatives induces hemolysis of human red blood cells at concentrations up to 200g/l in physiological solutions.