Effect of Antigen-Specific Immunoadsorption on Antibody Kinetics in a Rat Model

R. A. Zeuner 2nd Medical Clinic, Univ. of Kiel, Chemnitzstrasse, 33, D-2300, Kiel, FRG

R. Béress 2nd Medical Clinic, Univ. of Kiel, Chemnitzstrasse, 33, D-2300, Kiel, FRG

J. O. Schroeder 2nd Medical Clinic, Univ. of Kiel, Chemnitzstrasse, 33, D-2300, Kiel, FRG

K. M. Euler 2nd Medical Clinic, Univ. of Kiel, Chemnitzstrasse, 33, D-2300, Kiel, FRG

Abstract

The investigation of antibody kinetics following antigen-specific immunoadsorption in alkaline phosphatase immunized rats revealed significantly lower antibody levels than in untreated controls over a follow-up period of 6 weeks. A rebounding antibody synthesis as a result of specific depleüon was not observed. Non-adsorption of specific antiidiotypic antibodies may explain these findings.

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Effect of Antigen-Specific Immunoadsorption on Antibody Kinetics in a Rat Model

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Effect of Antigen-Specific Immunoadsorption on Antibody Kinetics in a Rat Model

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