76
Views
19
CrossRef citations to date
0
Altmetric
Original Article

The Use of Semifluorinated Alkanes in Blood-Substitutes

&
Pages 583-595 | Published online: 11 Jul 2009
 

Abstract

Semifluorinated alkanes are useful for blood-substitutes in two different ways: as co-surfactant to stabilize emulsions with perfluorocarbons as oxygen-carrier and as oxygen-carrier instead of perfluorocarbons. Semifluorinated alkanes act as co-surfactants in low concentrations because they are enriched at the interface perfluorodecalin/water. Emulsions with Semifluorinated alkanes dissolve about the same amount of oxygen as emulsions with perfluorocarbons. The stability of these emulsions depends on the nature of the alkyl and the perfluoroalkyl chain. Semifluorinated alkanes do not eliminate hydrogen fluoride under clean-up conditions of perfluorocarbons. According to toxicity tests against human carcinoma cells Semifluorinated alkanes with alkyl chains are harmless in the examined range from C6 to C10.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.