Two Types of Totally Artificial Red Blood Cell Substitutes Liposome Embedded Heme(L/H) and Hpidheme/Microsphere(LHM)

K. Kobayashi Department of Surgery, School of Medicine, Keio University, Tokyo, Japan; Department of Polymer Chemistry, Waseda University, Tokyo, Japan

T. Kakizaki Department of Surgery, School of Medicine, Keio University, Tokyo, Japan; Department of Polymer Chemistry, Waseda University, Tokyo, Japan

T. Komatsu Department of Surgery, School of Medicine, Keio University, Tokyo, Japan; Department of Polymer Chemistry, Waseda University, Tokyo, Japan

H. Nishide Department of Surgery, School of Medicine, Keio University, Tokyo, Japan; Department of Polymer Chemistry, Waseda University, Tokyo, Japan

E. Tsuchida Department of Surgery, School of Medicine, Keio University, Tokyo, Japan; Department of Polymer Chemistry, Waseda University, Tokyo, Japan

Abstract

Two types of totally artificial oxygen carriers were produced (1)by embedding synthetic lipidhemes (as oxygen carriers) in bilayers of liposomes as vehicles of lipidhemes (L/H) and (2)by covering clinically available fat droplets (triglyceride microspheres) with synthetic lipidhemes(LHM). Fat droplets were used as vehicles of lipidhemes. Their oxygen carrying ability in vivo was examined in beagles undergoing hemorrhagic shock. L/H delivered 15.7 to 19.2% of total oxygen delivery. From 12.7 to 24.4% of total oxygen consumption was from L/H. LHM delivered 11.6 to 7.3% of total oxygen delivery. From 13.1 to 16.4% of total oxygen consumption was from LHM.

These totally synthetic red blood cell substitutes can be candiates for futere clinical testing.

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Two Types of Totally Artificial Red Blood Cell Substitutes Liposome Embedded Heme(L/H) and Hpidheme/Microsphere(LHM)

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Two Types of Totally Artificial Red Blood Cell Substitutes Liposome Embedded Heme(L/H) and Hpidheme/Microsphere(LHM)

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