23
Views
24
CrossRef citations to date
0
Altmetric
Original Article

Lung Management with Perfluorocarbon Liquid Ventilation Improves Pulmonary Function and Gas Exchange During Extracorporeal Membrane Oxygenation (ECMO)

, , , , &
Pages 1389-1396 | Published online: 11 Jul 2009
 

Abstract

We investigated whether pulmonary function and gas exchange would improve with liquid perfluorocarbon ventilation (LV) during ECMO for severe respiratory failure. Lung injury was induced in 11 young sheep 15.1 ± 3.7 kg in weight utilizing right atrial injection of 0.07 cc/kg oleic acid followed by saline pulmonary lavage. When (A-a)DO2 ± 600 mmHg and PaO2 ± 50 mmHg with FiO2 = 1.0, ECMO was instituted. Animals were then ventilated with either standard ECMO “lung rest” gas ventilator settings (ECMO, n=5) or with “total” liquid ventilation at standard ventilator device settings (LIQ-ECMO, n=6) utilizing perflubron (perfluooctyl bromide, LiquiventTM; Alliance Pharmaceutical Corp.). After 3 hours on ECMO, pulmonary physiologic shunt decreased (ECMO = 88 ± 11% vs LIQ-ECMO = 31 ± 1%; p <. 001) and pulmonary compliance increased (ECMO = 0.50 ± 0.06 cc/cmH2O/kg vs. LIQ-ECMO = 1.04 ± 0.19 cc/cmH2O/kg; p <. 001). The ECMO flow rate required to maintain the PaO2 in the 50-80 mmHg range was decreased significantly (ECMO = 116 ± 14 ml/kg/min vs. LIQ-ECMO = 14 ± 5 ml/kg/min; p <. 001). In this model requiring extracorporeal support for severe respiratory failure, lung management with liquid ventilation improves pulmonary function and gas exchange.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.