Fluorinated Phospholipid-Based Vesicles as Potential Drug Carriers: Encapsulation/Sustaining of Drugs and Stability in Human Serum

F. Frezard Unité de Chimie Moléculaire, associée au Centre National de la Recherche Scientifique, Université de Nice-Sophia Antipolis, 06108, Nice Cédex, France

C. Santaella Unité de Chimie Moléculaire, associée au Centre National de la Recherche Scientifique, Université de Nice-Sophia Antipolis, 06108, Nice Cédex, France

P. Vierling Unité de Chimie Moléculaire, associée au Centre National de la Recherche Scientifique, Université de Nice-Sophia Antipolis, 06108, Nice Cédex, France

J. G. Riess Unité de Chimie Moléculaire, associée au Centre National de la Recherche Scientifique, Université de Nice-Sophia Antipolis, 06108, Nice Cédex, France

Abstract

The release of entrapped 5(6)-carboxyfluorescein from fluorinated vesicles in a buffer or in human serum is considerably less than that from hydrogenated liposomes. The presence of a fluorinated core inside the liposomal membrane definitely reduces its permeability. In some cases, the stability of liposomes made from fluorinated phospholipids alone is better than that of egg phosphatidylcholine cholesterol 1/1 vesicles, which are among the least permeable and most stable hydrogenated liposomes.

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Fluorinated Phospholipid-Based Vesicles as Potential Drug Carriers: Encapsulation/Sustaining of Drugs and Stability in Human Serum

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Fluorinated Phospholipid-Based Vesicles as Potential Drug Carriers: Encapsulation/Sustaining of Drugs and Stability in Human Serum

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