Imaging of Liposomes by Scanning Tunneling Microscopy

M. H. Zareie Department of Chemical Engineering and Bioengineering Division, Hacettepe University, Ankara, Turkey

A. Borucu Biotechnology Research Unit, Department of Biological Sciences, Middle East Technical University, Ankara, Turkey

M. Y. Özden Biotechnology Research Unit, Department of Biological Sciences, Middle East Technical University, Ankara, Turkey

V. Hasirci Biotechnology Research Unit, Department of Biological Sciences, Middle East Technical University, Ankara, Turkey

E. Pişkin Department of Chemical Engineering and Bioengineering Division, Hacettepe University, Ankara, Turkey

Abstract

In this study, unilamellar and multilamellar liposomes consisting of dipalmitoylphosphatidylcholine, cholesterol and dicetylphosphate were prepared. Scanning tunneling microscopy images of these liposomes on highly oriented pyrolytic graphite surfaces were obtained. It was observed that scanning tunnelling microscopy can be succesfully used for high-resolution, three-dimensional structure analysis of liposomes under very mild conditions.

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Imaging of Liposomes by Scanning Tunneling Microscopy

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Imaging of Liposomes by Scanning Tunneling Microscopy

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