Microdisperse Form of Immobilized Hemoglobin Modelling the Erythrocytes

Abstract

Disperse systems based on hemoglobin sorption immobilization in reticular carboxylic polyelectrolytes are proposed as model of erythrocytes. The efficiency of oxygen transport of these systems is much higher than that of native hemoglobin and is comparable with the gas transport of erythrocytes. This is belived to be due to highly selective sorption of hemoglobin in microdisperse forms of permeable polyelectrolytes. Microparticles of immobilized hemoglobin exibit high local concentration of hemoglobin: the protein mass being one order of magnitude than that of polymer-carrier. Besides, it is presumed that structure of the carboxylic polyelectrolyte matrix is a polymer analog of 2,3-diphosphoglycerate. Microdispersion of immobilized hemoglobin exhibits a aggregative resistance and have identity of surface charge with erytrocytes. Studies in vivo have revealed biocompatibility of immobilized hemoglobin.