Description of a Project for the Production and Evaluation of Oxygen-Carrying Hemosubstitutes

J. C. Briceño Fundación Cardio-Infantil Instituto de Cardiología, and Mechanical Engineering Department, University of Los Andes, P. O. Box 4976, Bogotá, D.C. COLOMBIA

I. E. Rincón Fundación Cardio-Infantil Instituto de Cardiología, and Mechanical Engineering Department, University of Los Andes, P. O. Box 4976, Bogotá, D.C. COLOMBIA

J. F. Vélez Fundación Cardio-Infantil Instituto de Cardiología, and Mechanical Engineering Department, University of Los Andes, P. O. Box 4976, Bogotá, D.C. COLOMBIA

A. García Fundación Cardio-Infantil Instituto de Cardiología, and Mechanical Engineering Department, University of Los Andes, P. O. Box 4976, Bogotá, D.C. COLOMBIA

I. Castro Fundación Cardio-Infantil Instituto de Cardiología, and Mechanical Engineering Department, University of Los Andes, P. O. Box 4976, Bogotá, D.C. COLOMBIA

M. Arias Fundación Cardio-Infantil Instituto de Cardiología, and Mechanical Engineering Department, University of Los Andes, P. O. Box 4976, Bogotá, D.C. COLOMBIA

C. Velásquez Fundación Cardio-Infantil Instituto de Cardiología, and Mechanical Engineering Department, University of Los Andes, P. O. Box 4976, Bogotá, D.C. COLOMBIA

M. L. Anzola Fundación Cardio-Infantil Instituto de Cardiología, and Mechanical Engineering Department, University of Los Andes, P. O. Box 4976, Bogotá, D.C. COLOMBIA

M. Matallana Fundación Cardio-Infantil Instituto de Cardiología, and Mechanical Engineering Department, University of Los Andes, P. O. Box 4976, Bogotá, D.C. COLOMBIA

C. E. Isaza Fundación Cardio-Infantil Instituto de Cardiología, and Mechanical Engineering Department, University of Los Andes, P. O. Box 4976, Bogotá, D.C. COLOMBIA

M. I. Arcos Fundación Cardio-Infantil Instituto de Cardiología, and Mechanical Engineering Department, University of Los Andes, P. O. Box 4976, Bogotá, D.C. COLOMBIA

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Abstract

Scarce availability and risk of transmission of infections and diseases (HIV, hepatitis B, Chagas' disease) limit the use and benefits of homologous blood transfusions for surgical purposes. Recent trials of perfluorocarbon-based hemosubstitutes (PFC-HSs) in experimental cardiopulmonary bypass (CPB) have demonstrated their ability to improve brain oxygenation, as compared with conventional crystalloid priming solutions. The objective of the project described here is to test different formulations of PFC-HSs and optimize their formulation and dosage for use in CPB. The project includes: (1) study the feasibility of implementing a laboratory for small scale production of PFC-HSs; (2) evaluate the efficacy of use of PFC-HSs in an animal model of CPB; and (3) evaluate the safety of use of PFC-HSs in an animal model of hemorrhagic shock. Several in-house PFC-HSs and outside PFC-HSs are being evaluated. The current state of the project is: (1) the feasibility study has been completed and several PFCs, emulsifiers and surfactants are being tested; (2) and (3) the animal models have been implemented are being used to test in-house and outside PFC-HSs as priming solutions in CPB and reinfusion fluids in hemorrhagic shock respectively. Some preliminary results are presented.

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Description of a Project for the Production and Evaluation of Oxygen-Carrying Hemosubstitutes

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