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Original Article

Preparation and Blood Compatibility of New Silica-Chitosan Hybrid Biomaterials

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Pages 431-436 | Published online: 04 Aug 2009
 

Abstract

The development of new materials containing both organic and inorganic structures is of great interest with respect to achievement of obtaining the special properties, and the sol-gel process has provided new opportunities for making such materials. In this paper, new silica-chitosan hybrid biomaterials were produced by this technique, using biopolymer chitosan and its heparin-like derivative as the organic species to be incorporated into the silicon alkoxide (TEOS) based network. All the samples made were in form of thin, flexible films with optical clarity. Microphase separated structure was observed in the hybrid surface, with hydrophobic Si02 and hydrophilic chitosan interleaved. These hybrid materials displayed good blood compatibility in comparison with their single component systems

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