Γ-aminobutyric acid receptors affect the progression and migration of tumor cells

Abstract

Γ-aminobutyric acid (GABA) is a multifunctional molecule found in the nervous system and non-neuronal tissues. GABA receptors combine with GABA molecules and transmit signal stimuli into cells. In addition to traditional neurotransmission and regulation of secretion, GABA and GABA receptors are involved in cell differentiation and proliferation throughout peripheral organs, as well as in tumorigenesis. The exact mechanism of the GABAergic system in regulating tumor development is unclear, but many studies have revealed that GABA receptors exert critical regulative effects on tumor cell proliferation and migration. In this review, the molecular structure, distribution and biological function of GABA receptors associated with tumorigenesis are described. Recent advances in the elucidation of mechanisms underlying GABAergic signaling control over tumor growth are also discussed.

• Cancer
• GABA
• GABA receptor
• signal pathway

Acknowledgements

The authors thank Prof. Zhang Haibo (Departments of Physiology and Medicine, University of Toronto, Toronto, ON, Canada, M5S 1C6) for fruitful discussions.