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Research Article

Rap2b promotes proliferation, migration, and invasion of lung cancer cells

, , &
Pages 459-464 | Received 29 Sep 2015, Accepted 16 Nov 2015, Published online: 16 Dec 2015
 

Abstract

Rap2b, a member of the guanosine triphosphate-binding proteins, is widely up-regulated in many types of tumors. However, the functional role of Rap2b in tumorigenesis of lung cancer remains to be fully elucidated. In this study, we investigated the effect of Rap2b on the lung cancer malignant phenotype, such as cell proliferation and metastasis. We found that Rap2b could promote the abilities of lung cancer cell wound healing, migration, and invasion via increasing matrix metalloproteinase-2 enzyme activity. Furthermore, Rap2b overexpression could increase the phosphorylation level of extracellular signal-regulated protein kinases 1/2. In conclusion, our results suggested that Rap2b may be a potential therapeutic target for lung cancer.

Declaration of interest

The authors report no declarations of interest.

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