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Abstract
In rat, chronic lithium treatment lowered the Kd of [3 H]-mepyramine in midbrain, and reduced the Bmax in midbrain and ponsmedulla. Binding of [3 H] flunitrazepam in cerebellum and midbrain was not altered. The suggestion that some actions of lithium may occur by way of central nervous system receptors is further supported by these observations that lithium's effects on neurotransmitter systems are regional and specific.