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Journal of Receptor Research Volume 4, 1984 - Issue 1-6
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Research Article

Characteristics of 3H-Tifluadom Binding in Guinea-Pig Brain Membranes

W. P. Burkard Pharmaceutical Research Department, F. Hoffmann-La Roche & Co., Limited Company, CH-4002, Basel, Switzerland
,
P. M. Müller Pharmaceutical Research Department, F. Hoffmann-La Roche & Co., Limited Company, CH-4002, Basel, Switzerland
&
N. Flück Pharmaceutical Research Department, F. Hoffmann-La Roche & Co., Limited Company, CH-4002, Basel, Switzerland
Pages 165-173 | Published online: 26 Sep 2008
 
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Abstract

3H-Tifluadom labels specifically recognition sites of opioid kappa receptors. Membranes of guinea-pig whole brain bind 3H-tifluadom with two affinities, in contrast to the cerebellum where almost all opioid sites are kappa.

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