Molecular Cloning of the Antagonist-Binding Subunit of the Glycine Receptor

Gabriele Grenningloh ZMBH, Universität Heidelberg, Im Neuenheimer Feld 282, D-6900, Heidelberg, FRG

Axel Rienitz ZMBH, Universität Heidelberg, Im Neuenheimer Feld 282, D-6900, Heidelberg, FRG

Bertram Schmitt ZMBH, Universität Heidelberg, Im Neuenheimer Feld 282, D-6900, Heidelberg, FRG

Christoph Methfessel Max-Planck-Institut für Biophysikalische Chemie, Auf dem Nikolausberg, D-3400, Göttingen, FRG

Monika Zensen Institut für Genetik, Weyertal 121, D-5000, Köln, FRG

Konrad Beyreuther Institut für Genetik, Weyertal 121, D-5000, Köln, FRG

Eckart D. Gundelfinger ZMBH, Universität Heidelberg, Im Neuenheimer Feld 282, D-6900, Heidelberg, FRG

Heinrich Betz ZMBH, Universität Heidelberg, Im Neuenheimer Feld 282, D-6900, Heidelberg, FRG

show all

Abstract

The postsynaptic receptor for the inhibitory neurotransmitter glycine is a heterooligomeric membrane protein which, after affinity purification on an antagonist column, contains three polypeptides of 48K, 58K and 93K. Sequencing of cDNA clones of the antagonist-binding 48K subunit revealed a structural organization similar to and significant amino acid homology with nicotinic acetylcholine receptor proteins. Our data suggest the existence of a set of related genes encoding transmembrane channel-forming neurotransmitter receptor polypeptides of excitable membranes.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Molecular Cloning of the Antagonist-Binding Subunit of the Glycine Receptor

Information for

Open access

Opportunities

Help and information

Molecular Cloning of the Antagonist-Binding Subunit of the Glycine Receptor

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature