Experimental and modeling approaches in characterizing coating uniformity in a pan coater: A literature review

Abstract

This review provides a comprehensive record of experimental and modeling approaches that can be used to study the effect of critical process parameters affecting the coating uniformity in pharmaceutical coating operation. Explicit reference is given to the development of the approach and its previous usage with particular emphasis on the advantages, limitations and model assumptions.

Keywords:

• Coating
• coefficient of variation
• particle tracking techniques
• modeling approaches
• tablets

Acknowledgments

The authors thank NSF-Center for Pharmaceutical Processing Research (CPPR) and University of Connecticut Research Foundation (UCRF) for the financial support of the work.

Declaration of interest

The authors report no conflicts of interest.