Early diagnosis and management of patients with familial ATTR amyloidosis receiving livers from asymptomatic variant TTR carriers

Abstract

The possibility of a with familial ATTR amyloidosis patient receiving a liver from an asymptomatic variant TTR carrier is remote. However, in 2008, it was reported that this unlikely event occurred in a patient in Portugal. We report our protocol for early diagnosis and management of this entity.

Keywords::

• Familial ATTR amyloidosis, familial amyloidotic polyneuropathy
• liver transplantation in familial amyloidotic polyneuropathy
• real-time polymerase chain reaction
• transthyretin

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Erratum

Acknowledgements

We wish to thank Prof. Luis Tomé for the clinical report, Dr. Marta Carrera for invaluable help with genetic information, and Jaume Munar-Bernat for technical assistance.

Declaration of interest: This work was partially funded by a research grant from Asociación Valverdeña de la Enfermedad de Andrade (Valverde del Camino, Huelva, Spain).