Simultaneous presentation of kappa-restricted chronic lymphocytic leukemia and lambda light chain AL amyloidosis

Gottfried von Keudell Department of Hematology and Oncology, University of Chicago, Chicago, IL, USACorrespondence[email protected]

Vaishali Sanchorawala Boston University School of Medicine, Boston, MA, USA; Amyloid Treatment and Research Program, Boston, MA, USA

Carl O’Hara Boston University School of Medicine, Boston, MA, USA

David C. Seldin Boston University School of Medicine, Boston, MA, USA; Amyloid Treatment and Research Program, Boston, MA, USA

J. Mark Sloan Boston University School of Medicine, Boston, MA, USA; Amyloid Treatment and Research Program, Boston, MA, USA

Abstract

We report on a 58-year-old man who presented with simultaneous kappa-restricted chronic lymphocytic leukemia (CLL) and a lambda-restricted plasma cell dyscrasia causing AL amyloidosis involving the kidney and GI tract. While monoclonal immunoglobulins occasionally produced by CLL has previously been implicated in AL amyloidosis, this is the first case of AL amyloidosis resulting from a distinct plasma cell dyscrasia that is not clonally related to the concurrent CLL. Appropriate treatment depended on detailed pathologic diagnosis of both disease processes.

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Simultaneous presentation of kappa-restricted chronic lymphocytic leukemia and lambda light chain AL amyloidosis

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Simultaneous presentation of kappa-restricted chronic lymphocytic leukemia and lambda light chain AL amyloidosis

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