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Biomarkers Volume 15, 2010 - Issue 6
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Original Article

Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancer

Xin An;State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, P. R. China
,
Pei-Rong Ding;Department of Medical Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China
,
Yu-Hong Li;Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China
,
Feng-Hua Wang;State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, P. R. China
,
Yan-Xia Shi;Department of Medical Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China
,
Zhi-Qiang Wang;Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China
,
You-Jian He;State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, P. R. China
,
Rui-Hua Xu;Department of Medical Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China
&
Wen-Qi Jiang;Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, P. R. ChinaCorrespondence[email protected]
 show all
Pages 516-522 | Received 16 Mar 2010, Accepted 04 May 2010, Published online: 05 Jul 2010
 
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Abstract

Background: Elevated neutrophil to lymphocyte ratio (NLR) is linked with worse survival in many malignancies, whereas its association with pancreatic cancer (PC) remains unclear.

Methods: We retrospectively reviewed 95 patients with locally advanced or metastatic PC receiving gemcitabine-based chemotherapy. The prognostic value of NLR was evaluated.

Results: Elevated pretreatment NLR (>5) was observed in 16 out of 89 eligible patients, which was identified as an independent prognostic factor for overall survival (OS). The median OS for patients with elevated and normal NLR were 2.4 months and 7.7 months, respectively (p <0.001).

Conclusions: Elevated NLR is a predictor of shorter survival in patients with advanced PC.

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