Assessment of serum levels of asymmetric dimethylarginine, symmetric dimethylarginine and l-arginine in coronary artery disease

Abstract

Serum asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), l-arginine, and C-reactive protein (hsCRP) levels were assessed in 100 Egyptian male 35–50-year-old patients with coronary artery disease (CAD), classified into: patients under conservative medical treatment, patients directed for percutaneous coronary interventions, patients directed for coronary artery bypass graft operation and patients suffering from acute myocardial infarction. Age- and sex-matched controls (n = 100) were included. Correlation between serum levels of biomarkers and dimethylarginine dimethylaminohydrolase-2 (DDAH-2) genotypes was studied. No association between biomarkers and carriage of the specific DDAH2 SNP2 (-449C/G, rs805305) genotype was detected. Further studies are required to confirm the contribution of the biomarkers in the predisposition of CAD.

Keywords::

• ADMA
• l-arginine
• coronary artery disease
• DDAH2 gene polymorphism
• Egyptians
• SDMA

Acknowledgements

We would like to thank Prof. R.H. Boger, Dr N. Lueneburg, and E. Shwedhelm, Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Universitätsklinikum Hamburg-Eppendorf, Germany for their kind support and help. Part of this work was done in the laboratory of Prof. Boger during an exchange visit funded by DAAD. We also thank Prof. Yehia Zakaria Gad, Department of Medical Molecular Genetics, National Research Center, Cairo for his guidance.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.