Polymorphisms in transcobalamin II gene is associated with coronary artery disease in Indian population

Abstract

Transcobalamin (TCII) is a key enzyme involved in intracellular transport of vitamin B12. We had earlier shown that vitamin B12 levels are associated with Coronary Artery Disease (CAD). Herein, we evaluated the association of four nonsynonymous single nucleotide polymorphisms (SNPs) of TCII gene with CAD in 1398 individuals (589 CAD cases and 809 controls). Using logistic regression, we found that three SNPs (G1196A, C776G and C1043T) were significantly associated with CAD and one (G1196A) with vitamin B12 levels even after controlling for confounding factors. Thus, polymorphisms in TCII gene may play an important role in the etiology of CAD.

Keywords::

• Coronary artery disease
• vitamin B₁₂
• transcobalamin
• single nucleotide polymorphism

Acknowledgments

All the authors acknowledge the participants of the study. GG and JK is thankful to the Council of Scientific and Industrial Research (CSIR) and University Grants Commission for fellowship, respectively. This study was supported by funds provided by CSIR (SIP 006), India.

Declaration of interest

The authors report no conflict of interest.