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Abstract
Objective: The role of adipokines in the development of cardiac syndrome X (CSX) remains unknown.
Methods: Fifty-nine CSX subjects were retrospectively enrolled from our catheterization databank. Another 54 subjects with valvular heart disease or arrhythmia served as controls. Adipokines were measured by ELISA tests.
Results: The CSX had lower circulating adiponectin but higher leptin and higher leptin/adiponectin ratio (×1000) (3.78 ± 4.96 vs. 2.14 ± 5.67, p < 0.001) than those of the controls. In a multivariate analysis, a higher leptin/adiponectin ratio was a predictor of CSX, while insulin-resistance index was not.
Conclusions: Adipokines may be implicated in the pathogenesis of CSX.
Acknowledgments
The authors would like to thank the Biostatistics Taskforce of Taichung Veterans General Hospital for statistical support.
Declaration of interest
This study was supported in part by grants from the Yen Tjing Ling Medical foundation, Taiwan (CI-99- 13), Taichung Veterans General Hospital, Taiwan (TCVGH-1003101B, 1007307C, TCVGH-NCHU997610, TCVGH-HK1008001) and the National Science Council, Taiwan (NSC-99-2311-B-075A-001). The authors declare no conflict of interest.