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Biomarkers Volume 18, 2013 - Issue 1
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Research Article

Serum fetuin-A levels are inversely associated with clinical severity in patients with primary knee osteoarthritis

Jie XiaoDepartment of Anesthesiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P. R. China
,
Xiang-Rui WangDepartment of Anesthesiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P. R. China
,
Kong-Zu HuDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Anhui Medical University, Anhui, P. R. China
,
Mao-Qiang LiDepartment of Orthopaedic Surgery, Hangzhou First People’s Hospital, Zhejiang, P. R. China
,
Jian-Wei ChenDepartment of Orthopaedic Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R.China
,
Tao MaDepartment of Orthopaedic Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R.China
&
Zhan-Chun LiDepartment of Orthopaedic Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R.ChinaCorrespondence[email protected]
 show all
Pages 51-54 | Received 14 Aug 2012, Accepted 12 Sep 2012, Published online: 16 Oct 2012
 
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Abstract

The present study aimed to detect serum fetuin-A levels in knee osteoarthritis (OA) patients and to investigate their correlation with clinical severity. We enrolled 215 knee OA patients and 76 healthy controls. We measured serum fetuin-A levels by enzyme-linked immunosorbent assay and assessed the correlation between serum fetuin-A levels and Kellgren-Lawrence grades as well as Western Ontario and McMaster Universities Arthritis Index scores in OA patients. Our results demonstrated that serum fetuin-A levels were independently and negatively correlated with greater clinical severity in OA patients.

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