Serum thymidine kinase 1 levels correlates with FDG uptake and prognosis in patients with non small cell lung cancer

Abstract

Context: TK1 found to be elevated biomarker in many solid cancers.

Objectives: The study aimed to assess the prognostic significance of a serum TK1 in patients with metastatic NSCLC.

Methods: The study included 48 consecutive patients, newly diagnosed with metastatic NSCLC, and 10 healthy volunteers. Serum TK1 activity determined by ELISA method.

Results: Patients with a bTK1 level >156 Du L^–1 had significantly shorter survival. TK1 level showed a strong correlation with primary tumor SUV_max.

Discussion and conclusion: The magnitude of maximum fluorodeoxyglucose uptake in primary tumors and the serum TK1 level in patients with metastatic NSCLC were found to be independent prognostic predictors of overall survival.

Keywords::

• Thymidine kinase 1(TK1)
• non small cell lung cancer
• DG uptake
• prognosis