Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer

Hyunsoo ChungTissue Array Research Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda, MDUSA

Hanbyoul ChoDepartment of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine SeoulKorea

Candice PerryTissue Array Research Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda, MDUSA

Jaekyung SongDepartment of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine SeoulKorea

Kris YlayaTissue Array Research Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda, MDUSA

Heejeong LeeDepartment of Pathology, Bucheon St. Mary’s Hospital, The Catholic University of Korea SeoulKoreaCorrespondence[email protected]
[email protected]

Jae-Hoon KimDepartment of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine SeoulKoreaCorrespondence[email protected]

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Abstract

Objective: We investigated the clinical significance of ERp57 in the progression of cervical cancer.

Methods: mRNA and protein expression of ERp57 in cervical neoplasias were examined.

Results: ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p < 0.001). Low ERp57 expression was significantly associated with worse overall survival (HR = 12.19, p = 0.018).

Conclusions: Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.

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Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer

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Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer

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