Characteristic molecular signatures of early exposure to volatile organic compounds in rat liver

Jeong Kyu KimDepartment of Pathology, College of Medicine, The Catholic University of Korea SeoulRepublic of Korea;Functional RNomics Research Center, College of Medicine, The Catholic University of Korea SeoulRepublic of Korea

Jung Woo EunDepartment of Pathology, College of Medicine, The Catholic University of Korea SeoulRepublic of Korea;Functional RNomics Research Center, College of Medicine, The Catholic University of Korea SeoulRepublic of Korea

Hyun Jin BaeDepartment of Pathology, College of Medicine, The Catholic University of Korea SeoulRepublic of Korea;Functional RNomics Research Center, College of Medicine, The Catholic University of Korea SeoulRepublic of Korea

Qingyu ShenDepartment of Pathology, College of Medicine, The Catholic University of Korea SeoulRepublic of Korea;Functional RNomics Research Center, College of Medicine, The Catholic University of Korea SeoulRepublic of Korea

Se Jin ParkDepartment of Pathology, College of Medicine, The Catholic University of Korea SeoulRepublic of Korea;Functional RNomics Research Center, College of Medicine, The Catholic University of Korea SeoulRepublic of Korea

Hyung Seok KimDepartment of Pathology, College of Medicine, The Catholic University of Korea SeoulRepublic of Korea;Functional RNomics Research Center, College of Medicine, The Catholic University of Korea SeoulRepublic of Korea

Soha ParkTechno-Art Division, Underwood International College, Yonsei University SeoulRepublic of Korea

Young Min AhnDepartment of Kidney System, College of Oriental Medicine, Kyung Hee University SeoulRepublic of Korea

Won Sang ParkDepartment of Pathology, College of Medicine, The Catholic University of Korea SeoulRepublic of Korea;Functional RNomics Research Center, College of Medicine, The Catholic University of Korea SeoulRepublic of Korea

Jung Young LeeDepartment of Pathology, College of Medicine, The Catholic University of Korea SeoulRepublic of Korea;Functional RNomics Research Center, College of Medicine, The Catholic University of Korea SeoulRepublic of Korea

Suk Woo NamDepartment of Pathology, College of Medicine, The Catholic University of Korea SeoulRepublic of Korea;Functional RNomics Research Center, College of Medicine, The Catholic University of Korea SeoulRepublic of Korea;Cancer Evolution Research Center, College of Medicine, The Catholic University of Korea SeoulRepublic of KoreaCorrespondence[email protected]

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Abstract

Objective: Investigation on whether the characteristic molecular signatures can discriminate individual volatile organic compounds (VOCs) and provide predictive markers for the detection of VOC exposure.

Methods: Transcriptomic analysis of liver tissues was performed 48 h after the single oral administration of three VOCs doses at LD₂₅ or LD₅ values, to Sprague-Dawley.

Results: Combination analysis of different multi-classifications suggested that 145 genes predicted VOC exposure. Additionally, Gene Set Enrichment Analysis of genes deregulated by VOCs revealed that T cell prolymphatic leukemia signaling was inactivated in all VOCs.

Conclusions: These molecular markers could be widely implemented to assess and predict environmental exposure to VOCs.

Keywords

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Characteristic molecular signatures of early exposure to volatile organic compounds in rat liver

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Characteristic molecular signatures of early exposure to volatile organic compounds in rat liver

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