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Abstract
Context: Cardiac surgery.
Objective: To compare plasma and urinary neutrophil gelatinase-associated lipocalin (P-/U-NGAL) in on-pump (n = 43) versus off-pump (n = 40) surgery.
Materials and methods: We obtained perioperative P-/U-NGAL and outcome data.
Results: P-/U-NGAL increased after surgery. P-NGAL was higher post-surgery in on pump patients (139 versus 67 µg L−1; p < 0.001), but not at 24 h. There were no differences in U-NGAL. Correlation between P-/U-NGAL and plasma creatinine was weak.
Discussion: P-NGAL acts like a neutrophil activation biomarker and U-NGAL like a tubular injury marker.
Conclusion: On-pump patients had greater neutrophil activation. On- versus off-pump surgery had similar impact on tubular cells.
Acknowledgements
We thank Leah Peck and Helen Young for their assistance with collection and measurement of NGAL levels.