Multiple MAGE-A genes as surveillance marker for the detection of circulating tumor cells in patients with ovarian cancer

Meixiang SangDepartment of Obstetrics and Gynecology, Bethune International Peace Hospital Shijiazhuang, HebeiPeople’s Republic of China;Tumor Research Institute, the Fourth Hospital of Hebei Medical University Shijiazhuang, HebeiPeople’s Republic of China

Xiaohua WuDepartment of Obstetrics and Gynecology, Bethune International Peace Hospital Shijiazhuang, HebeiPeople’s Republic of ChinaCorrespondence[email protected]

Xiaojie FanTumor Research Institute, the Fourth Hospital of Hebei Medical University Shijiazhuang, HebeiPeople’s Republic of China

Meijie SangTumor Research Institute, the Fourth Hospital of Hebei Medical University Shijiazhuang, HebeiPeople’s Republic of China;Department of Regenerative Medicine, Graduate School of Medicine and Pharmaceutical Science, University of Toyama Sugitani, ToyamaJapan

Xinliang ZhouTumor Research Institute, the Fourth Hospital of Hebei Medical University Shijiazhuang, HebeiPeople’s Republic of China

Nan ZhouDepartment of Obstetrics and Gynecology, Bethune International Peace Hospital Shijiazhuang, HebeiPeople’s Republic of China

Abstract

Ovarian cancer is a leading cause of death among gynecologic malignancies. In this study, we reported the expression of melanoma-associated antigens A (MAGE-A) genes in peripheral blood from 80 patients with ovarian cancer and 30 healthy donors. MAGE-As expression was associated with the factors indicating poor prognosis. The expressions of MAGE-As and each individual MAGE-A genes were also associated with low overall survival of patients with ovarian cancer. Our results suggested MAGE-A genes may have the potential to be surveillance markers for the detection of circulating tumor cells and represent a poor prognosis for patients with ovarian cancer.

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Acknowledgements

The authors would like to greatly appreciate Dr. Qianglin Duan, a skilled English proofreader from Tongji University for paper revision.

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Multiple MAGE-A genes as surveillance marker for the detection of circulating tumor cells in patients with ovarian cancer

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Multiple MAGE-A genes as surveillance marker for the detection of circulating tumor cells in patients with ovarian cancer

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