Fibrosis markers and CRIM1 increase in chronic heart failure of increasing severity

Abstract

Background: Fibrosis suppressors/activators in chronic heart failure (CHF) is a topic of investigation.

Aim: To quantify serum levels of fibrosis regulators in CHF.

Methods: ELISA tests were used to quantify fibrosis regulators, procollagen type-(PIP)I, (PIP)III, collagen-I, III, BMP1,2,3,7, SDF1α, CXCR4, fibulin 1,2,3, BMPER, CRIM1 and BAMBI in 66 CHF (NYHA class I, n = 9; II, n = 34; III n = 23), and in 14 controls.

Results: In CHF, TGFβR2, PIPIII, SDF1α and CRIM1 were increased. PIPIII correlated with CRIM1.

Conclusions: The BMPs inhibitor CRIM1 is increased and correlates with higher levels of serum PIPIII showing an imbalance in favor of pro-fibrotic mechanisms in CHF.

• Endothelial dysfunction
• heart fibrosis
• inflammation

Acknowledgements

The authors thank Ada Patriarca for technical assistance.