Advanced search
Publication Cover
Biomarkers Volume 19, 2014 - Issue 3
Submit an article Journal homepage
167
Views
23
CrossRef citations to date
0
Altmetric
Research Article

Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans

Mitchell R. McGillDepartment of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center Kansas City, KSUSA
,
Mengde CaoDepartment of Medicine, University of Florida Gainesville, FLUSA;Banyan Laboratories, Inc. Alachua, FLUSA
,
Archie SvetlovBanyan Laboratories, Inc. Alachua, FLUSA
,
Matthew R. SharpeDepartment of Internal Medicine, University of Kansas Hospital Kansas City, KSUSA
,
C. David WilliamsDepartment of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center Kansas City, KSUSA
,
Steven C. CurryDepartment of Medical Toxicology, Banner Good Samaritan Medical Center Phoenix, AZUSA;Department of Medicine, and Center for Toxicology and Pharmacology Education and Research, University of Arizona College of Medicine Phoenix, AZUSA
,
Anwar FarhoodDepartment of Pathology, St. David’s North Austin Medical Center Austin, TXUSA
,
Hartmut JaeschkeDepartment of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center Kansas City, KSUSACorrespondence[email protected]
[email protected]
&
Stanislav I. SvetlovDepartment of Medicine, University of Florida Gainesville, FLUSA;Banyan Laboratories, Inc. Alachua, FLUSACorrespondence[email protected]
 show all
Pages 222-230 | Received 10 Oct 2013, Accepted 20 Feb 2014, Published online: 06 Mar 2014
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

Context: New biomarkers are needed in acetaminophen (APAP) hepatotoxicity. Plasma argininosuccinate synthetase (ASS) is a promising candidate.

Objective: Characterize ASS in APAP hepatotoxicity.

Methods: ASS was measured in plasma from rodents and humans with APAP hepatotoxicity.

Results: In mice, ASS increased before injury, peaked before alanine aminotransferase (ALT) and decreased rapidly. Fischer rats had a greater increase in ASS relative to ALT. Patients with abnormal liver test results had very high ASS compared to controls. ASS appeared to increase early in some patients, and declined rapidly in all.

Conclusions: ASS may be a useful biomarker of acute cell death in APAP hepatotoxicity.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

Inflammasome activation and function in liver disease
Source: Springer Science and Business Media LLC
Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients.
Source: Informa Healthcare

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.