Is Symmetric Dimethylarginine a sensitive biomarker of subclinical kidney injury in children born with low birth weight?

Abstract

Objective: The aim of this study was to investigate if Symmetric Dimethylarginine (SDMA) is a sensitive biomarker of renal function and may predict subclinical kidney injury in low birth weight (LBW) children.

Methods: We studied 68 LBW children and 20 children as reference group. An enzyme-linked immunosorbent assay was used to measure serum SDMA and Cystatin C (Cys C).

Results: SDMA levels were higher in study groups compared to reference groups. There was a strong correlation between SDMA and Cys C, also SDMA negatively correlated with eGFR.

Conclusion: Elevated SDMA concentration may play an important role in pathogenesis of chronic kidney disease.

• Chronic kidney disease
• Cystatin C
• low birth weight
• Symmetric Dimethylarginine